GW24-e0789 The relationship between cognitive impairment and insulin resistance in elderly patients with hypertension

Objectives To investigate the relationship between cognitive impairment and insulin resistance in elderly patients with hypertension, so as to screen for cognitive impairment earlier in elderly patients with hypertension. Methods 132 patients were divided into two groups: cognitive impairment group (n = 61) and non-cognitive impairment group (n = 71), gender, age, education, BMI, WHR, TC, TG, CRP, HDL-C, LDL-C, Cr, FPG, FINS, HOMA-IR, SBP and DBP were compared between the two groups, and logistic regression was analysed. Results In cognitive impairment group, education was lower (44.26% vs 67.61%, P<0.01), the level of BMI (26.8 ± 2.2 vs 22.9 ± 2.3, P<0.01), WHR (0.93 ± 0.06 vs 0.81 ± 0.05, P<0.01), TG (2.3 ± 0.6 vs 1.7 ± 0.5, P<0.01), FPG (6.1 ± 1.3 vs 5.2 ± 0.9, P<0.01), FINS (21.7 ± 12.9 vs 9.3 ± 3.7, P<0.01), HOMA-IR (5.9 ± 3.1 vs 2.1 ± 1.3, P<0.01) were higher than the control group. In the logistic regression eduction (P<0.05), BMI (P<0.01), WHR (P<0.05) and HOMA-IR (P<0.05) were independent factors. Conclusions The education, BMI, WHR and HOMA-IR were independent factors of cognitive impairment in elderly patients with hypertension. Education was a protective factor and the others were risk factors. Insulin resistance was an important risk factor for the cognitive impairment in primary elderly hypertensive patients. Doctors should strengthen the early recognition of insulin resistance, in order to prevent cognitive impairment of elderly patients with hypertension. In light of current evidence, intervention toward early and effective management to reduce insulin resistance should have important implications for the prevention and treatment of cognitive impairment.