e0056 Correlation between viable myocardium and Pzf in swine model of acute myocardial infarction

Objective The aim of this study is to explore the relationship between the viable myocardium and Pzf of related coronary artery in swine model of acute myocardial. Methods 13 swines, received coronary arteriongraphy after anaesthetic tracheal cannula, the pressure of coronary arteries were measured through guiding wire and the distal flow velocity of left anterior descending coronary arteries measured through doppler wire. Drawing the pressure- flow velocity coordinate graph, then calculated Pzf. Blocked up distal of left anterior descending coronary arteries by angioplasty balloon for 60–90 min to establish the model of acute myocardial infarction. The Pzf were calculated repeadly. Analysis the Pzf difference between before and after the model of acute myocardial infarction established. Taken out of those swines' hearts after executed them, sliced the cardiac muscle to dye with TTc to detect the viable myocardium, then cutted them from the left ventricular myocardium. The percent value of area viable myocardium were estimated by calculated the ratio of weight of viable myocardium to whole left venricular myocardium Drawing the percent value of area viable myocardium—Pzf after the model of acute myocardial infarction established coordinate graph and observed relationship between them. Results 11 out of 13 swines were successfully established models of acute myocardial infarction by coronary occlusion. 2 swines died of entricular fibrillation after their coronaries were occluded 45 and 65 min respectively. The viable myocardium could be detected by using TTc dyeing. The result of statistics analysis confirmed that the percent value of area viable myocardium were negative correlation with Pzf. Conclusion The swine model of acute myocardial infarction can be established successfully by coronary occlusion with angioplasty balloon. The percent value of area viable myocardium were negative correlation with Pzf, which showed that Pzf was a new method to predict the area of viable myocardium after acute myocardial infarction.