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Synthesis of Novel Substituted Bis(benzimidazole)amine, N-Benzimidazole (benzothiazole)amine, and N-Benzimidazole(benzoxazole)amine Under Ultrasound Irradiation via Copper-Catalyzed Reaction
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In this work, novel bis(benzimidazole)amine, N-benzimidazole(benzothiazole)amine, and
N-benzimidazole(benzoxazole)amine have been synthesized via a one-pot, intramolecular cyclization
of 2-iodoaniline and 2-aminobenzimidazoles (thiazoles and oxazoles)-trichloroacetonitrile adduct
using copper(I) iodide and DMF under ultrasound-assisted reaction with moderate to good yields.
Using basic materials and simple and available reagents, gentle copper-catalyzed reaction conditions,
easy purification with the help of solvent, good yields, non-addition of ligands, application of a simple
and efficient sonochemical method, short reaction times, and the synthesis of 15 new heterocycle
compounds have been appreciable features of this protocol.
Title: Synthesis of Novel Substituted Bis(benzimidazole)amine, N-Benzimidazole (benzothiazole)amine, and N-Benzimidazole(benzoxazole)amine Under Ultrasound Irradiation via Copper-Catalyzed Reaction
Description:
In this work, novel bis(benzimidazole)amine, N-benzimidazole(benzothiazole)amine, and
N-benzimidazole(benzoxazole)amine have been synthesized via a one-pot, intramolecular cyclization
of 2-iodoaniline and 2-aminobenzimidazoles (thiazoles and oxazoles)-trichloroacetonitrile adduct
using copper(I) iodide and DMF under ultrasound-assisted reaction with moderate to good yields.
Using basic materials and simple and available reagents, gentle copper-catalyzed reaction conditions,
easy purification with the help of solvent, good yields, non-addition of ligands, application of a simple
and efficient sonochemical method, short reaction times, and the synthesis of 15 new heterocycle
compounds have been appreciable features of this protocol.
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