New method in assessment of blood plasma coagulation balance

Introduction: Thrombotic complications associated with disorders of hemostatic system are quite common among various categories of patients and require timely objective assessment of coagulation balance. Aim: To develop an integrated index of assessment of blood plasma coagulation balance using the method of ‘overall haemostasis potential,’ and to test its practical value in clinical settings. Material and methods: 179 patients were studied: 88 with chronic kidney disease (CKD) of VD stage, treated by program hemodialysis, and 91 with ischemic heart disease (IHD) after percutaneous transluminal coronary angioplasty (PTСA). The state of overall coagulation and fibrinolytic potentials was studied in all patients using the method of overall hemostasis potential (OHP). Based on this method, coagulation index (CI) was calculated and tested in such categories of patients. Results and discussion: Patients with stage VD CKD demonstrated the tendency to hypocoagulation, while those with coronary heart disease (CHD) and PTСA – significant hypercoagulation, being indicated by CI index. Conclusions: Patients with stage VD CKD have the tendency to hypocoagulation, while those with CHD and PTСA – to hypercoagulation. The integrated index suggested for assessment of coagulation potential – coagulation index – can adequately reflect coagulation balance disorders and considerably simplify their quantitative assessment.