Magic-NOVEL: Suppressing electron–electron coupling effects in pulsed DNP

Pulsed dynamic nuclear polarization (DNP) enhances the nuclear magnetic resonance sensitivity by coherently transferring electron spin polarization to dipolar coupled nuclear spins. Recently, many new pulsed DNP techniques such as NOVEL, TOP, XiX, TPPM, and BEAM have been introduced. Despite significant progress, numerous challenges remain unsolved. The electron–electron (e–e) interactions in these sequences can severely disrupt the efficiency of electron–nuclear (e–n) polarization transfer. In order to tackle this issue, we propose the magic-NOVEL DNP method, utilizing Lee–Goldburg decoupling to counteract e–e coupling effects. Our theoretical analysis and quantum mechanical simulations reveal that magic-NOVEL significantly improves the transfer efficiency of DNP, even at shorter e–e distances. This method offers a new perspective for advancing pulsed DNP techniques in systems with dense electron spin baths. Furthermore, we demonstrate the effectiveness of phase-modulated Lee–Goldburg sequences in improving pulsed DNP transfer.