MO841: Anxiety and Depression in Maintenance Hemodialysis Patients: Prevalence and Their Effects on Health-Related Quality of Life

Abstract BACKGROUND AND AIMS End-stage renal disease and hemodialysis (HD) can afflict psychological status of patients causing various mood disorders including anxiety and depression. These mood disorders can negatively affect quality of life (QOL) of those patients. The aims of the study are to assess prevalence of anxiety and depression, to explore their associated factors, and to discover impact of these disorders on QOL in maintenance hemodialysis (MHD) patients. METHOD This cross-sectional multi-centric study involved 298 patients, who were maintained on HD for >3 months, in 3 different HD centers in Delta, Egypt from January 2021 to May 2021. Sociodemographic and clinical data of patients were obtained from their records. Anxiety and depression of the patients were evaluated by the usage of the hospital anxiety and depression scale (HADS). This scale divides patients to normal, borderline cases and abnormal cases. Assessment of QOL of the patients was carried out by using Kidney Disease Quality of Life (KDQOLTM-36), which yields symptom/problem list, effect of kidney disease, burden of kidney disease, physical health composite (PHC) and mental health composite (MHC). Comparison between abnormal cases, borderline cases and normal subgroups of anxiety and depression was performed regards various collected data of the patients in addition to 5 component of QOL. RESULTS The present study was conducted on 298 MHD patients (male 176, 59.1%) with median age of 49 years and median duration of HD of 5 years. Anxiety cases and borderline cases were identified in 49.7%, 26.1% of the patients, respectively, while depression cases and borderline cases were recognized in 55% and 28.2% of the patients, respectively. Percentage of females was increased significantly in cases with anxiety (26.4%, 41% and 49%, respectively), which did not occur with depression cases. However, there was no statistically significant differences between 3 groups of depression and anxiety regarding age, educational level, comorbidities and socioeconomic status. Abnormal cases of depression and anxiety had significantly longer duration of HD than other two groups (P = 0.001 and 0.013, respectively). All five components of QOL showed statistically significant differences between 3 groups of anxiety and depression (Table 1). CONCLUSION Both anxiety and depression are prevalent among MHD patients. These disorders can afflict different components of QOL of those patients.