Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Development of candidate vaccines against infection caused by shiga-toxin producing Escherichia coli. Part 1
View through CrossRef
Shiga-toxin producing Escherichia coli (STEC) strains cause serious and life-threatening diseases, hemorrhagic colitis (HC) and associated hemolytic uremic syndrome (HUS). Antibacterial etiotropic therapy against these diseases are not recommended. There are no vaccines against human HA and HUS. The review provides materials on the design of various types of candidate vaccines against STEC strains and assessment of their immunogenic and protective properties in experiments on laboratory and farm animals. The prospects for the use of inactivated corpuscular and live (vector) vaccines, lipopolysaccharide vaccines, DNA vaccines and nanovaccines, vaccines based on bacterial cell membranes (ghost), as well as vaccines created by reverse vaccinology methods in practice are considered. Key words: STEC, hemorrhagic colitis, immunodominant antigens, shiga toxins, EspA, EspB, Tir, intimine, IgG, sIgA
Dynasty Publishing House
Title: Development of candidate vaccines against infection caused by shiga-toxin producing Escherichia coli. Part 1
Description:
Shiga-toxin producing Escherichia coli (STEC) strains cause serious and life-threatening diseases, hemorrhagic colitis (HC) and associated hemolytic uremic syndrome (HUS).
Antibacterial etiotropic therapy against these diseases are not recommended.
There are no vaccines against human HA and HUS.
The review provides materials on the design of various types of candidate vaccines against STEC strains and assessment of their immunogenic and protective properties in experiments on laboratory and farm animals.
The prospects for the use of inactivated corpuscular and live (vector) vaccines, lipopolysaccharide vaccines, DNA vaccines and nanovaccines, vaccines based on bacterial cell membranes (ghost), as well as vaccines created by reverse vaccinology methods in practice are considered.
Key words: STEC, hemorrhagic colitis, immunodominant antigens, shiga toxins, EspA, EspB, Tir, intimine, IgG, sIgA.
Related Results
Reducing High Pressure Processing Costs: Efficacious Alternatives to Current Standard Procedures in the Food Manufacturing Industry
Reducing High Pressure Processing Costs: Efficacious Alternatives to Current Standard Procedures in the Food Manufacturing Industry
Abstract
As a result of recent advancements in design and optimization of high-pressure processing units, the technology is gaining rapid adoption across various se...
Hybridization of Escherichia coli producing Shiga-like toxin I, Shiga-like toxin II, and a variant of Shiga-like toxin II with synthetic oligonucleotide probes
Hybridization of Escherichia coli producing Shiga-like toxin I, Shiga-like toxin II, and a variant of Shiga-like toxin II with synthetic oligonucleotide probes
Synthetic oligonucleotides, constructed from the nucleotide sequences of genes coding for the A subunit of Shiga-like toxin (SLT) I and the B subunit of SLT-II, were used as probes...
Development of candidate vaccines against infection caused by shiga-toxin producing Escherichia coli. Part 2
Development of candidate vaccines against infection caused by shiga-toxin producing Escherichia coli. Part 2
Prevention and treatment of hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS) caused by Shiga-toxin producing Escherichia coli (STEC) continues to be a public health con...
Genomic Subtraction To Identify and Characterize Sequences of Shiga Toxin-Producing
Escherichia coli
O91:H21
Genomic Subtraction To Identify and Characterize Sequences of Shiga Toxin-Producing
Escherichia coli
O91:H21
ABSTRACT
To identify Shiga toxin-producing
Escherichia coli
genes associated with severe human disease, a genomic subtraction techniq...
Evolution of Antimicrobial Resistance in Community vs. Hospital-Acquired Infections
Evolution of Antimicrobial Resistance in Community vs. Hospital-Acquired Infections
Abstract
Introduction
Hospitals are high-risk environments for infections. Despite the global recognition of these pathogens, few studies compare microorganisms from community-acqu...
Isolation of Shiga Toxin Producing Escherichia coli 0157:H7 from Environmental and Clinical Samples in Dhaka City
Isolation of Shiga Toxin Producing Escherichia coli 0157:H7 from Environmental and Clinical Samples in Dhaka City
Escherichia coli O157:H7, a Shiga toxin producing microbe was first acknowledged as a virulent organism in 1982 during an analysis of an outbreak of haemorrhagic colitis associated...
Binding affinities and molecular dynamics simulations of selected approved drugs and Mucuna pruriens phytoconstituents with Escherichia coli Shiga toxin
Binding affinities and molecular dynamics simulations of selected approved drugs and Mucuna pruriens phytoconstituents with Escherichia coli Shiga toxin
Shiga toxin (Stx)–producing Escherichia coli (STEC), also known as “verocytotoxin- producing E. coli” is a major food and waterborne pathogen of zoonotic origin. STEC infection is ...
Shiga-like-toxin-producing Escherichia coli in retail meats and cattle in Thailand
Shiga-like-toxin-producing Escherichia coli in retail meats and cattle in Thailand
Specific DNA probes were used to identify Shiga-like toxin I (SLT I)- and SLT II-producing Escherichia coli in vegetables, meats, cattle, and farm animals in Thailand. SLT-producin...