Abstract B61: Effects of anti-obesity dietary supplement DHEA on serum DHEA, DHEA-S, IGF-1 and IGFBP-3 in DMBA-induced breast cancer model.

Abstract Obesity has been epidemic in the US for over two decades. Obesity has been linked to the risk of development of various cancers, including breast cancer. Dehydroepiandrosterone (DHEA) is an over-the-counter dietary supplement used as an anti-cancer agent and anti-obesity supplement. The objectives of this study were to investigate the long-term effects of obesity and DHEA treatment on body weight gain and serum DHEA, DHEA-S, IGF-1and IGFBP-3 using 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumor model. Forty-three six-week-old obese female Zucker rats were used. Rats were randomly assigned and had ad libitum access to water and a diet of either chow (2016) as a control diet or chow with the addition of DHEA at a concentration of 6 g/kg of chow as a DHEA diet. All rats were orally gavaged at age 50 days with 65 mg DMBA/kg body weight and were sacrificed 155 days post-DMBA treatment. Fifty-five percent (55%) of the control diet group developed mammary tumors, while no tumors were detected in the DHEA diet group (P<0.001). Obese rats fed the DHEA diet gained significantly less weight (P<0.001) and had an increased (P<0.001) serum DHEA and DHEA-S compared to control rats. Also, obese DHEA-Fed rats had significantly (P<0.001) lower serum IGF-1 and IGF-BP3. Our results suggest that DHEA treatment can reduce body weight gain by lowering serum IGF-1 and IGFBP-3 which might protects against breast cancer development caused by obesity. Also, this results suggests that breast cancer risk may be due to genetic predisposition to obesity might be related to body weight gain. It also suggests that these individuals could potentially reduce their risk by actively combating the weight gain. Supported by ABI to RH. Citation Format: Reza Hakkak, Soheila Korourian. Effects of anti-obesity dietary supplement DHEA on serum DHEA, DHEA-S, IGF-1 and IGFBP-3 in DMBA-induced breast cancer model. [abstract]. In: Proceedings of the Fifth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2012 Oct 27-30; San Diego, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2012;21(10 Suppl):Abstract nr B61.