Autologous Platelet Gel Healing Effects on Cutaneous Leishmaniasis Wounds 

Abstract Background and Objectives Autologous platelet gel (APG) has healing growth factors and is used in most surgeries to treat a variety of tissue defects. This study was conducted to investigate the healing effects of APG on cutaneous leishmaniasis (CL) wounds. Materials and Methods In this clinical trial, 15 patients with CL were recruited and followed for two months. The patients had more than one cutaneous wound, one of which was examined as the control and the other one as the intervention wound. APG was applied to the intervention wounds once a week, up to eight times. The response to treatment was evaluated base on the histopathology analyses. Results The use of APG on the wounds in the intervention group was associated with complete and faster healing in 66% of the cases and partial healing in 34% of the wounds. During study, none of the control wounds were completely healed. Following eight weeks treatment of CL lesions with APG, the inflammatory process in the epidermis, and dermis were decreased significantly. Conclusion This study demonstrated for the first time that APG can be effective in wound healing and removal of scars caused by CL. Trial registration IRCT, IRCT20190212042694N1. Registered 20 February 2019, https://en.irct.ir/trial/37522