Combinations of mycotoxins in feed and their accumulation in internal organs of broiler chickens

The issue of safety of production and processing of agricultural raw materials for obtaining quality food is becoming more and more topical. Of particular concern in most countries of the world is the contamination with mycotoxins of plant and livestock products. Plant food is contaminated as a result of pathogenic fungi growth, and livestock due to the accumulation of toxins in the body. They enter the human food chain continuously dire0ctly with cereals, seeds, spices, fruit, drinks and other plant products, as well as directly through food obtained from animals and birds that have consumed feed contaminated with mycotoxins. The real threat from mycotoxins can be extremely high, as they accumulate in the tissues and internal organs of animals and birds, and the consumption of broiler meat is increasing every year, being a more accessible protein product. Because of the small molecular weight of mycotoxins, the body does not produce antibodies to them, thus no immunity occurs, so warm-blooded animals and humans remain sensitive to them throughout life. The aim of our investigation (research) was: 1 - to determine the effect of fodder contaminated with a combined group of mycotoxins (Fumonizin B1, Zearalenone, DON and T-2 toxin) exceeding the maximum allowable concentration on growth and development of young chickens. 2-determine histological changes in the structures of internal organs (liver and kidney), which are directly related to the general health of broiler chickens. Under the influence of mycotoxins the liver is subjected to dystrophic changes. It increases in volume, changes the structure of the liver becoming brittle or friable, the color becomes pale or filled with blood. Sinusoidal capillaries are filled with blood, perivascular infiltration with round cellular elements in the area of triads. Granulomas - clusters of lymphoid cells appear in thickness of lobules. Among lymphoid cells a large number of hepatocytes in a state of hyaline-droplet dystrophy and in a state of necrosis. In the kidneys cause edema in the middle part of the cortical substance, due to which, subcapsular renal corpuscles are pushed back to the kidney capsule and capillaries overflow with blood. Vascular glomeruli thickening decrease in size and go into a state of disintegration of loops. In the convoluted tubules, some cells are in a state of hyaline-capillary dystrophy, some - in a state of necrosis, resulting in violation of the architectonics of the tubule, subcapsular hemorrhages appear. Causes venous hyperemia.