LCP2 expression is correlated with an abundance of immune infiltrates and is a potential prognostic biomarker in lung adenocarcinoma

AbstractObjective:To investigate the effect of LCP2 expression in lung adenocarcinoma on the prognosis and microenvironment of patients.Methods:The expression of LCP2 in lung adenocarcinoma tissues and normal tissue samples were analyzed by the TCGA database. Kaplan–Meier survival analysis was used to evaluate the relationship between expression level and prognosis of patients. The effect of differential expression of LCP2 on tumor cells was verified by Colony formation, CCK-8, wound healing, Transwell, and apoptosis. To analyze the relationship between LCP2 expression and immune infiltration in lung adenocarcinoma cells. The expression level of LCP2 was significantly correlated with tumor immune cell infiltration and immune checkpoint expressionResults:LCP2 expression was downregulated in lung adenocarcinoma, and patients with a low expression level of lung adenocarcinoma had a poor prognosis. LCP2 overexpression significantly inhibited the proliferation, migration, invasion, and tumor sphere formation potential. LCP2 overexpression enhanced apoptosis. The expression level of LCP2 was significantly correlated with tumor immune cell infiltration and immune checkpoint expression.Conclusion:The expression of LCP2 is low in lung adenocarcinoma, which is related to the prognosis and tumor immunity of lung adenocarcinoma patients, and can be used as a potential target for the treatment of lung adenocarcinoma patients