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PHF8 and REST/NRSF co-occupy gene promoters to regulate proximal gene expression
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AbstractChromatin regulators play an important role in the development of human diseases. In this study, we focused on Plant Homeo Domain Finger protein 8 (PHF8), a chromatin regulator that has attracted special concern recently. PHF8 is a histone lysine demethylase ubiquitously expressed in nuclei. Mutations of PHF8 are associated with X-linked mental retardation. It usually functions as a transcriptional co-activator by associating with H3K4me3 and RNA polymerase II. We found that PHF8 may associate with another regulator, REST/NRSF, predominately at promoter regions via studying several published PHF8 chromatin immunoprecipitation-sequencing (ChIP-Seq) datasets. Our analysis suggested that PHF8 not only activates but may also repress gene expression.
Springer Science and Business Media LLC
Title: PHF8 and REST/NRSF co-occupy gene promoters to regulate proximal gene expression
Description:
AbstractChromatin regulators play an important role in the development of human diseases.
In this study, we focused on Plant Homeo Domain Finger protein 8 (PHF8), a chromatin regulator that has attracted special concern recently.
PHF8 is a histone lysine demethylase ubiquitously expressed in nuclei.
Mutations of PHF8 are associated with X-linked mental retardation.
It usually functions as a transcriptional co-activator by associating with H3K4me3 and RNA polymerase II.
We found that PHF8 may associate with another regulator, REST/NRSF, predominately at promoter regions via studying several published PHF8 chromatin immunoprecipitation-sequencing (ChIP-Seq) datasets.
Our analysis suggested that PHF8 not only activates but may also repress gene expression.
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