CLINICAL AND BIOCHEMICAL STUDY OF POLYCYSTIC OVARIES SYNDROME IN YOUNG FEMALE POPULATION OF KHYBER PAKHTUNKHWA, PAKISTAN.

BACKGROUND: Polycystic ovaries syndrome (PCOS) is one of the commonest endocrine disorder inwomen. It is associated with characteristic metabolic disturbance, clinically manifested in the form ofamenorrhea, oligomenorrhoea. The present study was conducted on young females of district Peshawarand Mardan to investigate PCOS on the basis of clinical and biochemical findings.OBJECTIVE: To study clinical and biochemical feature regarding polycystic ovaries syndromes inyoung females of districts Peshawar and Mardan, Khyber Pkhutunkhwkha Pakistan.PATIENTS & METHOD: It was a cross sectional study of university going female students with agegroup of 20 to 25 years. A pre-designed, pre-tested questionnaire was used for the collection of data.Total T, SHBG, LH, were measured, each hormone in a single assay, using an automatedimmunochemiluminescence method (Immulite, Diagnostic Products, Los Angeles, CA). 17-OHP wasmeasured by direct Enzyme-linked immunosorbent Assay (ELISA) method.RESULTS: A total nine hundred& twenty six (n=926) females were randomly selected. General andclinical features include age, amenorrhea, oligomenorrhoea, acne, hirsutism, obesity and transabdominal ultrasound. The biochemical characteristics like hyper LH secretion of the 49.13% (n=455)subject were in a moderate range. In addition to 58.63% (n=543), 37.25% (n=345), 4.10% (n=38) of thewomen diagnosed with ACTH were in normal, low and high ranges respectively. Four eighty nine(n=489) women (52.80%) showed acyclic estrogen production in normal ranges while 23.97% (n=222)have in low ranges score and 23.21% (n=215) have high ranges of acyclic estrogen production.CONCLUSIONS: Polycystic ovaries are very common in this age group but are not necessarilyassociated with other signs and symptoms. The prevalence of polycystic ovary syndrome varies widelyaccording to the definition applied. Sub-group analysis of women with polycystic ovaries according tothe presence or absence of features of polycystic ovary syndrome does not reveal an increasing trend forprogression of endocrine abnormalities usually associated with polycystic ovary syndrome.KEYWORDS: Polycystic Ovaries Syndrome (PCOS), Peshawar, Mardan, KPK