Urinary excretion of electrolytes and their correlation with clinical parameters in chronic kidney disease

Introduction: With the increasing incidence of chronic renal disease on a global scale, it is important to document the chemical abnormalities that not only indicate deteriorating renal function, but also aggravate the clinical picture by causing sustained electrolyte imbalance, ultimately contributing to End Stage Renal Disease (ESRD). Objective: To investigate 24-hr urinary electrolytes excretion of non-dialysis patients presenting with history of chronic kidney disease (CKD) and correlate the biochemical abnormalities with clinical parameters. Materials & Methods: A total of 100 patients with CKD were included in a private clinic setup from February 2017 to December 2019 to retrospectively analyze the relationship of 24-hr urinary electrolytes with clinical indicators in these subjects. Besides demographic data, biochemical indices of concern were obtained through standard laboratory techniques. The patients were then divided on the basis of results into four quartile groups. Descriptive data analysis was done through SPSS 22.0. Results: Nephropathic patients had low eGFR, albumin, hemoglobin, blood calcium as well as 24-hr urine calcium and had high body mass index (BMI), systolic blood pressure, diastolic blood pressure, blood creatinine, blood sodium and 24-hr urine sodium. According to quartiles of 24-hr urinary sodium; in the Q4 group, 24-hr urine protein, 24-hr urine potassium and 24-hr urine calcium were the highest while according to quartile of 24-hr urinary potassium; the Q3 group had the highest 24-hr urine protein. According to quartile of urinary calcium, Q4 group blood calcium, 24-hr urine sodium and 24-hr urine potassium was high. The results revealed a positive correlation of 24-hr urinary sodium and potassium with 24-hr urine protein and a negative correlation of 24⁃hr urinary calcium with 24-hr urine protein. Conclusion: The levels of urinary electrolytes in patients with CKD are associated with urinary protein. It is, therefore, recommended that the above-mentioned disease be treated in these patients for their proper management. Keywords: Urine Chemistry; Proteinuria; Renal Insufficiency, Chronic.