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Multiplexed biosensors for precision bacteria tropism in vivo
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AbstractThe engineering of microbes spurs biotechnological innovations, but requires control mechanisms to confine growth within defined environments for translation. Here we engineer bacterial growth tropism to sense and grow in response to specified oxygen, pH, and lactate signatures. Coupling biosensors to drive essential gene expression reveals engineered bacterial localization within upper or lower gastrointestinal tract. Multiplexing biosensors in an AND logic-gate architecture reduced bacterial off-target colonization in vivo.
Cold Spring Harbor Laboratory
Title: Multiplexed biosensors for precision bacteria tropism in vivo
Description:
AbstractThe engineering of microbes spurs biotechnological innovations, but requires control mechanisms to confine growth within defined environments for translation.
Here we engineer bacterial growth tropism to sense and grow in response to specified oxygen, pH, and lactate signatures.
Coupling biosensors to drive essential gene expression reveals engineered bacterial localization within upper or lower gastrointestinal tract.
Multiplexing biosensors in an AND logic-gate architecture reduced bacterial off-target colonization in vivo.
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