Risk factors for atherosclerosis development in patients with systemic scleroderma

Systemic scleroderma (SSc), also known as systemic sclerosis, is a rare autoimmune disorder characterized by fibrosis of the skin and internal organs, as well as vascular abnormalities. Atherosclerosis, the accumulation of lipids and fibrous tissue in arterial walls, is a significant cause of cardiovascular morbidity and mortality. Patients with systemic scleroderma are at an elevated risk for developing atherosclerosis, with vascular damage playing a central role in its pathogenesis. This article reviews the multifactorial risk factors contributing to the development of atherosclerosis in patients with systemic scleroderma, focusing on endothelial dysfunction, chronic inflammation, dyslipidemia, and other clinical factors. The goal of this article is to enhance the understanding of cardiovascular risk in this population and emphasize the importance of early diagnosis and targeted interventions.