GW24-e2194 Low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio on admission is associated with clinical outcome in patients with ST segment elevation myocardial infarction undergoing urgent percutaneous coronary intervention

Objectives To analyse the relationship between low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio on admission and cardiovascular events in patients with ST segment elevation myocardial infarction (STEMI) undergoing urgent percutaneous coronary intervention (PCI). Methods A total of 387 patients who underwent urgent PCI with STEMI were enrolled. The patients were divided into two groups according to their median LDL-C/HDL-C ratio on admission: low LDL-C/HDL-C group (LDL-C /HDL-C ratio ≤ 2.50 mmol/L, n = 225) and high LDL-C/HDL-C group (LDL-C /HDL-C ratio > 2.50 mmol/L, n = 162). In the two groups, incidence of major adverse cardiovascular events (MACE) and readmission for cardiovascular events was collected during follow-up. MACE was defined as cardiovascular death, non-fatal MI, revascularisation, and stroke. Results The median duration of follow-up was 399.20 ± 61.68 days. The incidences of stroke and MACE were higher significantly in high LDL-C/HDL-C group than in low LDL-C/HDL-C group (stroke: 5.7% vs. 1.8%, P = 0.040; MACE: 13.2% vs. 6.3%, P = 0.021). After adjusting various confounders, the incidences of stroke and MACE significantly correlated with LDL-C/HDL-C ratio (hazard ratio (HR) = 9.048, 95% confidence interval (CI): 1.026–79.792, P = 0.047; HR = 2.975, 95% CI: 1.004–8.819, P = 0.049, respectively); the incidence of readmission for cardiovascular events significantly correlated with LDL-C (HR = 8.055, 95% CI: 1.605–39.326, P = 0.01). Conclusions The study suggested that the LDL-C/HDL-C ratio on admission had an impact on cardiovascular events, and the LDL-C/HDL-C ratio was a more useful predictor of cardiovascular events than the individual levels of LDL-C and HDL-C in patients with STEMI undergo urgent PCI.