Abstract 6186: HPV vaccine hesitancy and uptake: A conceptual analysis using Rodgers' evolutionary approach

Abstract Aim: This study examines the factors contributing to HPV vaccine hesitancy through Rodgers's evolutionary concept analysis, with a focus on the role of uncertainties surrounding the vaccine's impact on preventing HPV-related diseases despite its availability.Design: Rodgers's evolutionary concept analysis was employed to investigate factors influencing HPV vaccine hesitancy. The analysis considered studies published in English within the past five years (2019 - 2024), excluding those older than five years, non-English publications, and studies focused on other vaccines. Data Sources: To ensure a thorough review, a comprehensive literature search was conducted across key databases, including PsycINFO, CINAHL, MEDLINE, and PubMed. Relevant keywords such as “HPV” and “vaccine hesitancy” were used. Review Methods: Following PRISMA guidelines, 29 articles were selected for analysis: 19 quantitative studies, 8 qualitative studies, and 2 mixed-methods studies. The analysis explored factors related to HPV vaccine hesitancy, examining antecedents, attributes, and consequences. Results: Key antecedents identified included cultural beliefs, educational level, knowledge, and vaccine availability, along with factors like insurance status, perceived risk, and decision-making processes. Significant attributes influencing hesitancy involved media coverage, environmental and community influences, social factors, trust in healthcare, efficacy rates, and safety concerns. Consequences of hesitancy were noted as lower vaccine uptake, increased HPV-related diseases, and the persistence of misinformation. Conclusion: This study underscores the complex interaction of factors contributing to HPV vaccine hesitancy. Addressing these factors is essential to overcoming vaccine hesitancy challenges and creating effective intervention strategies. Impact: This analysis's findings provide valuable insights into public health strategies for enhancing vaccine uptake and reducing HPV-related diseases. Targeted efforts to address misinformation and build vaccine trust can improve public health outcomes. Patient or Public Contribution: This concept analysis was conducted without the direct involvement of patients, service users, caregivers, or members of the public. Citation Format: Grace Kwakyewaa Kyei, Evans F. Kyei, Rockson Ansong. HPV vaccine hesitancy and uptake: A conceptual analysis using Rodgers' evolutionary approach [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 6186.