A review on the neuroprotective potential of tamarindus indica: evidence from preclinical studies done between 2016 to 2023

Neurological disorders like Alzheimer's and Parkinson's disease present substantial challenges globally. Despite advancements in health sciences, effective treatments for neurodegenerative conditions remain elusive. Tamarindus indica, a tropical tree with a rich history in traditional medicine, holds promise as a potential neuroprotective agent due to its diverse phytochemical composition. This narrative review aims to evaluate Tamarindus indica's neuroprotective potential by systematically analyzing studies published in English Language retrieved from PubMed, Scopus databases, and Google Scholar. The algorithm ("Tamarindus indica" OR "tamarind") AND (Brain OR neuroprotect* OR behavioural OR neurodegenerative diseases OR Alzheimer's OR Parkinson's) was run on the two databases and search engine on the 2nd of October 2023 without any filters. Tamarindus indica, possesses phytochemicals such as flavonoids, alkaloids, and tannins, contributing to its medicinal properties. Despite its medicinal significance, caution is advised regarding the toxicity of certain components like seeds and potential allergic reactions. Nevertheless, research indicates its anti-inflammatory and antioxidant, mainly attributed to its flavonoids content, suggesting neuroprotective effects that could mitigate oxidative stress, lipid peroxidation, neuroinflammation and neuroexcitotoxicity, which are pivotal factors in neurodegeneration. While promising, a comprehensive understanding of Tamarindus indica's mechanisms, clinical applications, and safety profile is warranted. Further investigation is essential to unlock its therapeutic potential in combating neurodegenerative diseases. Tamarindus indica stands as a hopeful natural resource, necessitating continued exploration to harness its neuroprotective properties for improved neural health.