ODP174 Correlation of Advanced Fibrosis and Coronary Artery Disease Risk Scores in People With Type 2 Diabetes in a Tertiary Care Centre

Abstract Nonalcoholic fatty liver disease (NAFLD) and Type 2 diabetes mellitus (T2DM) are common conditions that often coexist and can act synergistically to cause adverse effects. The presence of both NAFLD and T2DM increases the likelihood of developing diabetes complications (including both macro and microvascular complications), and enhances the risk of cirrhosis, hepatocellular carcinoma and death. NAFLD screening is often neglected in routine clinical practice. Fibro scan is a more sensitive modality for diagnosis of liver fibrosis and scarring. Liver stiffness measurements predict advanced fibrosis in people with diabetes The current study aims to correlate liver stiffness measurements and coronary artery disease risk scores in people with type 2 diabetes in a tertiary care centre Material and Methods: - A total of 181 people with diabetes coming for the first time at our centre underwent liver stiffness measurements using fibro scan after taking consent, people on prior lipid-lowering therapy and thiazolidinedione therapy were excluded from the study. We used the risk score model for the assessment of coronary artery disease in asymptomatic patients with type 2 diabetes [ https://paperpile.com/c/XKqsdv/PpmxP 1 ] because it was easy to use, specific for Asian population and validated with coronary computed tomographic angiography (CCTA) in asymptomatic people with type 2 diabetes. Out of the total of 181 subjects 51% were males and 49% were females, mean age was 50.2 years, duration of diabetes was 7.6years, Hba1c values ranged from 6. 0%-15%(mean 8.5%), median stiffness ranged from 2.3kpa to 34.8kpa (median of 8. 0kpa).50 out of 181(27.62%) had advanced fibrosis(liver stiffness measurements(LSM values of >9. 0). Advanced fibrosis had a significant(p<. 001) correlation with coronary artery risk scores with a correlation coefficient of 0.570. Advanced fibrosis is associated with increased risk of coronary artery disease in people with type 2 diabetes BIBLIOGRAPHY 1. http://paperpile.com/b/XKqsdv/PpmxP. Park G-M, An H, Lee S-W, Cho Y-R, Gil EH, Her SH, et al. Risk Score Model for the Assessment of Coronary Artery Disease in Asymptomatic Patients With Type 2 Diabetes. Medicine [Internet]. 2015 Jan [cited 2020 Oct 14];94(4): e508. Available from: https://journals.lww.com/md-journal/Fulltext/2015/01040/Risk_Score_Model_for_the_Assessment_of_Coronary.44.aspx Presentation: No date and time listed