Reduced iopromide elimination in hemodialysis with cuprophan membranes

Purpose: To evaluate the influence of different membrane materials on the efficiency of iopromide elimination. Material and Methods: Twenty stable patients with chronic renal failure after coronary angiography were investigated for contrast medium elimination during hemodialysis directly after contrast medium application. Results: Clearance during hemodialysis with cuprophan membranes was 102±7 mg/ml in contrast to 153±4 mg/ml in polysulfone membranes. Elimination half-time was 94±5 min in cuprophan and 79±3 min in polysulfone membranes, and the elimination rate after 120 min was 59±2% and 66±1.5%, respectively. Plasma clearance of iopromide was elevated in polysulfone membranes (188±17 ml/min); however, not significantly different to cuprophane membranes (153±11 ml/min). Accordingly, 24-h urinary iopromide excretion was reduced to 26±4 g/24 h vs. 32±7 g/24 h. Conclusion: Hemodialysis for iopromide elimination with polysulfone membranes is more effective than with cuprophan membranes.