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CEACAM1 - A Promising Biomarker for Melanoma
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Abstract
Malignant melanoma is the third most common skin cancer, but it also remains the most aggressive. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a promising diagnostic and prognostic biomarker for melanoma, because its expression is important for tumour development. This review aims at highlighting the most recent discoveries regarding CEACAM1 and its correlation to the diagnosis and prognosis of malignant melanoma. National Library of Medicine (NIH) PubMed was used for selecting articles published between 2004-2021, based on their relevance and novelty. With its multiple and somewhat contradictory effects, CEACAM1 seems to influence melanoma invasion, migration, immunomodulation and tumour suppression, serving as a useful diagnostic biomarker and target for therapy. While the incidence of malignant melanoma has been increasing over the last decades without signs of prognosis improvement, it is crucial that new biomarkers for diagnosis and detection of metastatic progression are discovered, and CEACAM1 might be a viable option.
Fundatia pentru Sanatate Publica si Managementul Sanatatii
Title: CEACAM1 - A Promising Biomarker for Melanoma
Description:
Abstract
Malignant melanoma is the third most common skin cancer, but it also remains the most aggressive.
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a promising diagnostic and prognostic biomarker for melanoma, because its expression is important for tumour development.
This review aims at highlighting the most recent discoveries regarding CEACAM1 and its correlation to the diagnosis and prognosis of malignant melanoma.
National Library of Medicine (NIH) PubMed was used for selecting articles published between 2004-2021, based on their relevance and novelty.
With its multiple and somewhat contradictory effects, CEACAM1 seems to influence melanoma invasion, migration, immunomodulation and tumour suppression, serving as a useful diagnostic biomarker and target for therapy.
While the incidence of malignant melanoma has been increasing over the last decades without signs of prognosis improvement, it is crucial that new biomarkers for diagnosis and detection of metastatic progression are discovered, and CEACAM1 might be a viable option.
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<div>Abstract<p>CEACAM1 (biliary glycoprotein-1, CD66a) was reported as a strong clinical predictor of poor prognosis in melanoma. We have previously identified CEACAM1...
Data from Novel Immunotherapy for Malignant Melanoma with a Monoclonal Antibody That Blocks CEACAM1 Homophilic Interactions
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<div>Abstract<p>CEACAM1 (biliary glycoprotein-1, CD66a) was reported as a strong clinical predictor of poor prognosis in melanoma. We have previously identified CEACAM1...
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