Long-term results of radical surgical interventions for malignant neoplasms of the pancreatoduodenal zone, complicated by the syndrome of mechanical jaundice

One of the priority tasks of modern oncopancreatology is the involvement of new strategies to improve patient’s survival rates. Aim - to analyze and compare the course of the long-term period after pancreatoduodenal resection in patients with malignant tumors of the pancreatoduodenal zone, complicated by the syndrome of mechanical jaundice. Materials and methods. The long-term results of surgical treatment of 101 patients with malignant neoplasms of the pancreatobiliary area, complicated by the syndrome of mechanical jaundice, were analyzed. The main group included 33 (32.7%) patients in whom pancreatoduodenal resection was combined with extended lymphodissection; the comparison group included 68 (67.3%) patients who underwent a similar operation, but lymphodissection was performed in the standard volume.Variational and non-parametric statistics methods were used. Results. The overall 1-year survival rates of patients in the main group and the comparison group were not significantly different and amounted to 71.3% and 69.2%. Median survival after standard PDR was 15.8 months, after extended - 20.2 months. The overall disease-free 1-year survival rates of patients in the main group and the comparison group did not differ significantly and amounted to 54.1% and 48.3%. Median disease-free survival in the main group was 15 months, and in the comparison group - 12 months. Conclusions. According to the results of the comparative analysis of long-term results, the use of pancreaticoduodenal resection of different lymph node dissection volume in patients of the compared groups did not reveal statistically significant differences in survival. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.