Inflammatory Biomarkers in Rosacea Patients

Aims: Rosacea is a chronic inflammatory skin disease characterized by telangiectasia, papules and pustules associated with immune response. Several factors, especially inflammatory factors, have been investigated in its etiopathogenesis. The Systemic Immune Inflammation Index (SII) is a novel inflammation marker. It has recently been used to evaluate the inflammatory and immune status of the patients. Also, several studies investigated other inflammation markers such as neutrophil/lymphocyte (NLR) and platelet/lymphocyte (PLR) ratios. The present study aims to investigate the correlation between rosacea, an inflammatory disease, and inflammatory markers such as platelet (PLT), lymphocyte (LYM), neutrophil (NEU), NLR, PLR, and especially SII. Methods:The study was conducted with 100 papulopustular rosacea patients and 100 healthy controls. The patient and control groups were similar in age and gender. Participant data and laboratory results were obtained retrospectively from the patient files. Results: Seventy-eight of the rosacea patients were female and 22 were male. The mean participant age was 47.97. There was no significant difference between rosacea patients and the control group based on age and gender. The PLT and LYM markers were significantly lower in the patient group when compared to the control group, and NLR, PLR and SII markers were significantly higher in the patient group (p<0.05). Conclusion: The significant difference between the investigated inflammatory parameters suggested that rosacea could be a systemic inflammatory disease rather than a simple skin inflammation. More comprehensive studies are required to clarify this premise and the correlation between rosacea and systemic inflammation.