Immunomodulatory and Antioxidant Action of Selective Inhibitor of Arginase IInor-NOHA and Antihypoxants in Some Extreme Conditions

The study of the effects of a selective inhibitor of arginase II nor-NOHA and its combinations with Hy-poxenum, Kudesan, Cytoflavin on the functional activity of neutrophils, lipid peroxidation and content of stable metabolites of nitrogen in the blood serum of rats under the influence of some extreme conditions was carried out. It was found that under conditions of hypoxia that occurs in some extreme situations, there is a reduction of spontaneous and induced phagocytic and metabolic activity of neutrophils. Combined application of nor-NOHA, hypoxen and cytoflavin increases spontaneous PMA of neutrophils to values of the control group, but does not influence the values of NST Ind. The authors found that at hypoxia, there is an increase in the content of primary and secondary products of lipid peroxidation. Administration nor-NOHA and antihypoxants reduces the concentration of malondialdehyde at all combinations of drugs, and reduction of diene conjugates only in animals treated with nor-NOHA, hypoxen and cytoflavin. Total antioxidant activity increased as well, for all combinations of pharmacological agents, and catalase activity was increased combinations nor-NOHA + cytoflavin and nor-NOHA + hypoxen + cytoflavin. At hypoxia, there is a significant increase of stable NO metabolites in blood serum. Introduction nor-NOHA further increases their concentration, and at different combinations antigipoksantov administered in combination with an inhibitor of arginase II nor-NOHA marked reduction of NO metabolite to an animal in a state of hypoxia.