Curcumin Attenuates Hepato-, and Nephrotoxicity Induced by Cypermethrin Through Inhibition of Oxidative Stress in Male Albino Rabbits

Abstract The reactive oxygen species (ROS) have been involved in the toxicity of several pesticides. This study was aimed to induce oxidative stress in rabbit’s liver and kidney by cypermethrin (CYP), a type II pyrethroid pesticide and to evaluate the protective effect of Curcumin (CMN). Numerous plant moieties are identified to exhibit protective potential by neutralizing the oxidative stress. In this study we evaluated the protective role of powdered dried rhizome of curcuma longa L. (CMN) against CYP-induced liver and renal toxicity. For this purpose, all the rabbits were divided in 4 groups, each containing 5 rabbits. The 1st group considered as control while 2nd, 3rd and 4th group were treated with CYP (25mg/kg), CMN (50 mg/kg) alone and CYP (25 mg/kg) in combination with CMN (50 mg/kg), respectively. Biochemical markers were investigated in serum while antioxidant potential and histopathological analysis was performed in liver and kidney tissues. CYP administration resulted in significant reduction of antioxidant protein and enzymes (GSH, GST, catalase, SOD and GPx). Moreover, remarkable variations were observed in biochemical markers (urea, creatinine, AST, ALT, ALP and bilirubin) as well as in histology of kidney and liver in CYP-treated rabbits. The administration of CMN in combination with CYP significantly restored the level of endogenous antioxidants. Furthermore, the normal level of serum biochemical markers was observed with normal histology of liver and kidney in rabbits treated with CMN. Similarly, CMN alleviated the harmful effects of CYP on lipid profiles, hematological parameters and body weight of rabbits.