Identification of risk factors for hyperamylasemia during laparoscopy-assisted surgery for colorectal cancer: a retrospective cohort study

Abstract Background: Many complications are frequently reported in the carbon dioxide pneumoperitoneum surgery, except hyperamylasemia occurring in pancreas.Methods: Using data from 380 patients with colorectal cancer registered for a prospective cohort study comparing postoperative serum amylase level, risk factors for postoperative hyperamylasemia and surgical complications were identified by multivariate logistic regression analysis.Results: Hyperamylasemia occurred in 140 patients, and a total of 52 patients in 380 patients had short-term postoperative complications, including 25 patients with hyperamylasemia in which 2 patients with acute pancreatitis. The method of operation, injury of pancreas during operation, the duration of pneumoperitoneum and intraoperative blood loss were significant predictors of hyperamylasemia. However, the economic significance of this phenomenon is not certain.Conclusion: High incidence of hyperamylasemia in laparoscopy-assisted surgery for colorectal cancer, the incidence of postoperative infectious complications will increase significantly. Surgical treatment of rectal cancer, operation around the pancreas, intraoperative blood loss, duration of pneumoperitoneum should be considered when planning surgery. Although patient’s hospital cost and postoperative hospital stay were well documented, it is unclear whether this is of any economic significance.Trial registration: The study was registered with the China Clinical Trial Registry with registration number ChiCTR1800015311 and was registered on March 22, 2018.