Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Magnesium-Catalyzed N2-Regioselective Alkylation of 3-Substituted Pyrazoles
View through CrossRef
A highly regioselective Mg-catalyzed alkylation of 3-substituted pyrazoles has been developed to provide N2-alkylated regioisomers. Using α-bromoacetates and acetamides as alkylating agents, this new method was applied to a variety of 3-substituted and 3,4-disubstituted pyrazoles to produce the N2-alkylated products with high regioselectivities ranging from 76:24 to 99:1 and 44–90% yields.
Georg Thieme Verlag KG
Title: Magnesium-Catalyzed N2-Regioselective Alkylation of 3-Substituted Pyrazoles
Description:
A highly regioselective Mg-catalyzed alkylation of 3-substituted pyrazoles has been developed to provide N2-alkylated regioisomers.
Using α-bromoacetates and acetamides as alkylating agents, this new method was applied to a variety of 3-substituted and 3,4-disubstituted pyrazoles to produce the N2-alkylated products with high regioselectivities ranging from 76:24 to 99:1 and 44–90% yields.
Related Results
Resource-efficient technology for the utilization of serpentine technogenic waste with the production of magnesium oxide
Resource-efficient technology for the utilization of serpentine technogenic waste with the production of magnesium oxide
The article discusses the possibility of using serpentine and serpentine waste from Zhitikara deposit for the production of inorganic magnesium compounds: MgSO4, Mg(OH)2 and MgO. T...
What is the Proper Composition of the Dialysate Magnesium and How Much Magnesium is Removed During Pre-Dilution Online Hemodiafiltration?
What is the Proper Composition of the Dialysate Magnesium and How Much Magnesium is Removed During Pre-Dilution Online Hemodiafiltration?
Aim: The aim of the study was to determine the ideal dialysate magnesium during hemodialysis, knowing that the
solution used is not satisfactory and is often associated with low se...
PRL Phosphatases Promote Tumor Progression by Regulating the Level of Intracellular Magnesium
PRL Phosphatases Promote Tumor Progression by Regulating the Level of Intracellular Magnesium
The Phosphatase of Regenerative Liver (PRL) enzymes (PRL‐1,‐2,‐3; gene name PTP4A1, PTP4A2, PTP4A3) are members of the protein tyrosine phosphatase family. These enzymes have been ...
Investigating The Agreement of Hypomagnesemia Diagnosis in Three Perimeter of Serum, Urine, and Red Blood Cell in Intensive Care Unit: Pilot Study
Investigating The Agreement of Hypomagnesemia Diagnosis in Three Perimeter of Serum, Urine, and Red Blood Cell in Intensive Care Unit: Pilot Study
Background: Magnesium is a vital element in the body involved in biochemical and physiological processes. Magnesium deficiency can lead to serious consequences including cardiac, n...
Chemical Synthesis of Substituted Naphthalene Derivatives: A Review
Chemical Synthesis of Substituted Naphthalene Derivatives: A Review
AbstractThis review outlines progress in the synthesis of substituted naphthalene derivatives. Naphthalene and its derivatives exhibit various biological activities such as anti-in...
Study on the effect and mechanism of gold nanocoated magnesium bone scaffolds for bone repair
Study on the effect and mechanism of gold nanocoated magnesium bone scaffolds for bone repair
Abstract
Background:
Bone defects caused by trauma, tumors, and infections are common orthopedic diseases. Currently, the most commonly used treatment for bone defects is b...
Biocompatibility Study of Silica-Based Magnesium Composites: A Review
Biocompatibility Study of Silica-Based Magnesium Composites: A Review
Because of their exceptional biodegradability, mechanical strength, and biocompatibility, magnesium-based composites have attracted a lot of interest in the biomedical field. This ...
Serum magnesium and adverse prognosis in acute pancreatitis with acute kidney injury: a MIMIC-IV retrospective study
Serum magnesium and adverse prognosis in acute pancreatitis with acute kidney injury: a MIMIC-IV retrospective study
Abstract
Acute pancreatitis (AP) concurrent with acute kidney injury (AKI) remarkably elevates the risk of adverse outcomes in affected indiv...