Nonhemorrhagic Primary Obstetric Shock

<i>Objective:</i> Clinical evaluation of nonhemorrhagic primary obstetric shock (NHPOS). <i>Methods:</i> In a retrospective clinical study, data on 8 cases of NHPOS were analyzed. Data on patient age, parity, week of gestation, comorbidity, possible etiologic trigger, course of disease with clinical picture and laboratory findings of coagulopathy, and patient outcome including autopsy findings in two lethal outcomes were analyzed. <i>Results:</i> These 8 patients were treated in the intensive care unit. One patient died during delivery from cardiopulmonary arrest in the state of irreversible obstetric shock, verified by massive pulmonary thromboembolism at autopsy. Another patient died from stroke and cerebral coma caused by trophoblastic cerebrovascular embolism 5 days after artificial abortion, showing a clinical picture of shock and cardiopulmonary arrest. In 1 patient, severe septic shock developed several hours after premature stillbirth and abruptio placentae in the 26th week of pregnancy, associated with disseminated intravascular coagulopathy. Four patients developed intrapartum NHPOS, with a clinical picture of chest pain, dyspnea, tachycardia, hypotension, cyanosis, and disseminated intravascular coagulopathy, as demonstrated by laboratory findings. Based on clinical picture and laboratory findings, amniotic fluid embolism or trophoblastic embolism was suspected. All these patients survived. One patient developed NHPOS during the third labor stage after vacuum extraction because of a macrosomic child, followed by disseminated intravascular coagulopathy and secondary hemorrhage which necessitated B-Lynch procedures and total hysterectomy for massive bleeding. Hereditary thrombophilia was detected in subsequent patients. <i>Conclusions:</i> NHPOS can be caused by amniotic fluid embolism, trophoblastic embolism or thromboembolism, and sepsis. These conditions may frequently prove fatal due to their abrupt and unexpected course, mostly during pregnancy, delivery, or immediately thereafter.