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Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity
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Significance
Glia and neurons, the two principal cell types of the nervous system, interact intimately and are critical for normal development and function of the nervous system. While much is known about glia interaction with axons, the architecture and importance of glia interaction with the somatodendritic neuronal compartment is practically unknown. Using
Drosophila
as a model system, we have identified important and previously unknown roles for glia interaction with the somatodendritic compartment in dendrite structure, activity, and regeneration. Furthermore, recent clinical studies have shown patients with ATRX mutations exhibit white matter and glial abnormalities in their central nervous system, underscoring the significance of our study that uncovers an essential role for glial-expressed ATRX in mediating proper glial development and function.
Proceedings of the National Academy of Sciences
Title: Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity
Description:
Significance
Glia and neurons, the two principal cell types of the nervous system, interact intimately and are critical for normal development and function of the nervous system.
While much is known about glia interaction with axons, the architecture and importance of glia interaction with the somatodendritic neuronal compartment is practically unknown.
Using
Drosophila
as a model system, we have identified important and previously unknown roles for glia interaction with the somatodendritic compartment in dendrite structure, activity, and regeneration.
Furthermore, recent clinical studies have shown patients with ATRX mutations exhibit white matter and glial abnormalities in their central nervous system, underscoring the significance of our study that uncovers an essential role for glial-expressed ATRX in mediating proper glial development and function.
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