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Primary Sclerosing Cholangitis
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Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic disease characterized by inflammation and fibrosis that may involve the entire biliary tree. The fibrosis causes diffuse narrowing of the intrahepatic and extrahepatic bile ducts, and the resulting biliary stasis leads to secondary biliary cirrhosis and associated complications. This review addresses PSC through its epidemiology, etiopathogenesis, diagnosis, differential diagnosis, management, complications, and prognosis. Figures show pouchoscopy, liver biopsy, and endoscopic retrograde cholangiopancreatography; direct peroral cholangioscopy visualization of cholangiocarcinoma; and algorithms depicting diagnosis of cholangiocarcinoma and screening for inflammatory bowel disease (IBD) in patients with PSC. Tables list characteristics of IBD in PSC, prevalence of antibodies in PSC, differential diagnosis of PSC, diagnostic approach in PSC, and risk of cancers in PSC.
This review contains 6 highly rendered figures, 5 tables, and 91 references.
Title: Primary Sclerosing Cholangitis
Description:
Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic disease characterized by inflammation and fibrosis that may involve the entire biliary tree.
The fibrosis causes diffuse narrowing of the intrahepatic and extrahepatic bile ducts, and the resulting biliary stasis leads to secondary biliary cirrhosis and associated complications.
This review addresses PSC through its epidemiology, etiopathogenesis, diagnosis, differential diagnosis, management, complications, and prognosis.
Figures show pouchoscopy, liver biopsy, and endoscopic retrograde cholangiopancreatography; direct peroral cholangioscopy visualization of cholangiocarcinoma; and algorithms depicting diagnosis of cholangiocarcinoma and screening for inflammatory bowel disease (IBD) in patients with PSC.
Tables list characteristics of IBD in PSC, prevalence of antibodies in PSC, differential diagnosis of PSC, diagnostic approach in PSC, and risk of cancers in PSC.
This review contains 6 highly rendered figures, 5 tables, and 91 references.
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Autoimmune Hepatitis/Overlap Syndromes
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When autoimmune hepatitis has features of primary biliary cholangitis or primary sclerosing cholangitis, these mixed clinical phenotypes constitute overlap syndromes. Diagnostic cr...
Autoimmune Hepatitis/Overlap Syndromes
Autoimmune Hepatitis/Overlap Syndromes
When autoimmune hepatitis has features of primary biliary cholangitis or primary sclerosing cholangitis, these mixed clinical phenotypes constitute overlap syndromes. Diagnostic cr...
Risk Factors, Physicians’ Practice and Outcomes of Post-Kasai Cholangitis
Risk Factors, Physicians’ Practice and Outcomes of Post-Kasai Cholangitis
Abstract
Background
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Chronic sclerosing cholangitis and recurrent pulmonary infections in two brothers associated with cellular immunodeficiency and increased cytokine production
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Role of intraductal antibiotic in preventing cholangitis in post-endoscopic retrograde cholangiopancreatography patients
Role of intraductal antibiotic in preventing cholangitis in post-endoscopic retrograde cholangiopancreatography patients
Background
Acute cholangitis is one of the most serious life-threatening post-endoscopic retrograde cholangiopancreatography (ERCP) complications. Some have suggested t...