New Gleason grade groups; epidemiologic data from Isfahan, Iran based on the new classification

Introduction: A new five-tier Gleason grade grouping (GGG) has recently been proposed and approved by the World Health Organization. In this new classification, GGG 1 (Gleason score ≤6), GGG 2 (Gleason score 3+4=7), GGG 3 (Gleason score 4+3=7), GGG 4 (Gleason score 8) and GGG 5 (Gleason score 9-10) are the new grade groups based on the Gleason score. Objectives: We examined the epidemiologic data of prostate cancer based on the new Gleason system in Isfahan, Iran. International Society of Urological Pathology (ISUP) proposed the new Gleason grade groups in order to make accurate prognostic classification for prostate cancer. Patients and Methods: Around 305 prostate cancer cases which diagnosed by biopsy admitted to Khorshid university hospital and Ordibehesht surgical center were included (from 2014 to 2016). Pathological examination of the samples was conducted by pathologists with genitourinary expertise. Results: Among 305 biopsy specimens, 28.6% of cases had a Gleason score less than 6, 23.7% Gleason score 3+4=7, 10.9% Gleason score 4+3=7, only 0.7% Gleason score 4+4=8 and 36.1% Gleason score 9 and 10. Conclusion: The new Gleason grade groups provide a simplified, user-friendly and clear classification system for predicting prognosis and disease progression before and after treatment.