Correlation of Lower Limb Alignment with Mensical Meniscal Extrusion in Knee Osteoarthritis

Abstract [Objective] This study aims to explore the relationship between Lower limb alignment parameters and the degree of Meniscal Medial Extrusion (MME) in patients with Knee Osteoarthritis (KOA), in hopes of providing new reference data for the prevention and treatment of KOA. [Methods] A retrospective study design was employed, analyzing 623 KOA patients treated at our hospital from 2022 to 2023, with 307 patients' information collected according to inclusion and exclusion criteria. Patients were divided into mild and severe groups based on the degree of MME, and differences in Lower limb alignment parameters between the two groups were compared, including AMA, JLCA, mLDFA, MPTA, FKJL, FTA, and mHKA. Univariate analysis, Pearson correlation analysis, and multivariate stepwise regression analysis were used, along with ROC curve assessment to evaluate the predictive value of Lower limb alignment parameters on the degree of MME. [Results] Univariate analysis showed significant correlations between AMA, JLCA, mLDFA, MPTA, and the degree of MME (P < 0.05). Pearson correlation analysis further confirmed the positive correlations between these parameters and the degree of MME. Multivariate stepwise regression analysis indicated that AMA, JLCA, and mLDFA are significant independent predictors of the severity of MME. ROC analysis suggested that the combination of AMA, JLCA, and mLDFA could better predict severe MME. When the values of AMA, JLCA, and mLDFA exceed 6.33°, 3.55°, and 86.34°, respectively, MME ≥ 0.3cm, significantly increasing the risk of MME. [Conclusion] AMA, JLCA, and mLDFA are closely related to the degree of MME in KOA patients and can serve as important parameters for assessing the severity of MME, holding significant implications for the early prevention and treatment of KOA.