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Complex evolution of porcine endogenous retroviruses
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Abstract
Background: Porcine endogenous retroviruses (PERVs) are proviruses that can replicate in human cells. However, the evolutionary process leading to the generation of modern PERVs is not well understood.Results: We mined 14 pig genomes and other available 304 mammalian genomes in silico, which led to the documentation of 185 full-length PERVs. Notably, we found two novel ERVs in the lesser Egyptian jerboa ( Jaculus jaculus ) and rock hyrax ( Procavia capensis ) named ERV-Gamma-Jja and ERV-Gamma-Pca, respectively, which were the source of the modern PERVs. Phylogenetic analyses provided evidence for the multiple origins of PERVs involving hosts of rodents, rock hyrax, and pigs. Conclusion: These new findings help us to understand the complex evolution of the modern PERVs.
Title: Complex evolution of porcine endogenous retroviruses
Description:
Abstract
Background: Porcine endogenous retroviruses (PERVs) are proviruses that can replicate in human cells.
However, the evolutionary process leading to the generation of modern PERVs is not well understood.
Results: We mined 14 pig genomes and other available 304 mammalian genomes in silico, which led to the documentation of 185 full-length PERVs.
Notably, we found two novel ERVs in the lesser Egyptian jerboa ( Jaculus jaculus ) and rock hyrax ( Procavia capensis ) named ERV-Gamma-Jja and ERV-Gamma-Pca, respectively, which were the source of the modern PERVs.
Phylogenetic analyses provided evidence for the multiple origins of PERVs involving hosts of rodents, rock hyrax, and pigs.
Conclusion: These new findings help us to understand the complex evolution of the modern PERVs.
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