Research Advances in Molecular Docking for Screening Antiviral Drugs Against Enteroviruses

Enteroviruses are important pathogens that cause a range of human diseases, including Hand, foot and mouth disease and aseptic meningitis. The traditional development process of antiviral drugs is not only time-consuming and costly but also difficult to cope with various viral mutations. In recent years, with the rapid development of computer-aided drug design technology, molecular docking technology has been widely used in the screening of effective drug components, the discovery of targets for enteroviruses, and the exploration of the action mechanisms of antiviral drugs against enteroviruses. This article reviewed the application of molecular docking technology in the screening of antiviral drugs against enteroviruses, the mechanisms of action of antiviral drugs against enteroviruses, and the identification of targets for antiviral drugs against enteroviruses, aiming to provide a more sufficient rationale for the screening of antiviral drugs against enteroviruses and the development of new drugs.