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Probable mechanism of action and Gas Chromatography - Mass Spectroscopy Profile of the antimalarial fractions of the hexane seed extract of Garcinia kola (GUTTIFERAE)
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To access the antimalarial activity, mechanism of action and constituents of the hexane extract of Garcinia kola (GK) seeds and its column-fractions. The in vivo antimalarial activity of the hexane extract of GK and its column-fractions against Chloroquine-resistant Plasmodium berghei (ANKA) strain, the mechanism of action and the chemical constituents of the column fractions was determined using the Peters’ 4-day suppressive test, the beta hematin assay and Gas chromatography- mass spectrometry respectively. In this study, Fractions 4,5,15 and 95 obtained from the hexane extract of Garcinia kola seeds using column chromatography produced chemosuppression values ≥ 59.6% at 200 mg/kg. These fractions inhibited the conversion of heme to heamozoin and contained arenes following Gas chromatography-mass spectrometry. The observed antimalarial activity justifies the use of Garcinia kola seeds in the treatment of febrile illnesses.
UK Journal of Pharmaceutical and Biosciences
Title: Probable mechanism of action and Gas Chromatography - Mass Spectroscopy Profile of the antimalarial fractions of the hexane seed extract of Garcinia kola (GUTTIFERAE)
Description:
To access the antimalarial activity, mechanism of action and constituents of the hexane extract of Garcinia kola (GK) seeds and its column-fractions.
The in vivo antimalarial activity of the hexane extract of GK and its column-fractions against Chloroquine-resistant Plasmodium berghei (ANKA) strain, the mechanism of action and the chemical constituents of the column fractions was determined using the Peters’ 4-day suppressive test, the beta hematin assay and Gas chromatography- mass spectrometry respectively.
In this study, Fractions 4,5,15 and 95 obtained from the hexane extract of Garcinia kola seeds using column chromatography produced chemosuppression values ≥ 59.
6% at 200 mg/kg.
These fractions inhibited the conversion of heme to heamozoin and contained arenes following Gas chromatography-mass spectrometry.
The observed antimalarial activity justifies the use of Garcinia kola seeds in the treatment of febrile illnesses.
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In vitro
antimalarial activity of
Garcinia parvifolia
Miq. Stem extracts and fractions on
Plasmodium falciparum
lactate dehydrogenase (LDH) assay
In vitro
antimalarial activity of
Garcinia parvifolia
Miq. Stem extracts and fractions on
Plasmodium falciparum
lactate dehydrogenase (LDH) assay
Abstract
Objectives
The rapid spread of antimalarial drug resistance is becoming a problem in the ...
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