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Stromal Demarcation Line in Pulsed Versus Continuous Light Accelerated Corneal Cross-linking for Keratoconus
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PURPOSE:
To compare the stromal demarcation line depth in pulsed versus continuous corneal cross-linking (CXL) for keratoconus.
METHODS:
Seventy eyes underwent epithelium-off cross-linking, with 0.1% riboflavin applied during 10 minutes prior to ultraviolet irradiation at 30 mW/cm
2
. Thirty-six eyes received pulsed irradiation (1 second on, 1 second off) for 8 minutes and 34 eyes underwent continuous irradiation for 4 minutes. Total fluence was 7.2 J/cm
2
for both groups. Patients were evaluated at 3 months after the procedure.
RESULTS:
A significantly deeper stromal demarcation line was observed in the pulsed group compared to the continuous group (201.11 ± 27.76 vs 159.88 ± 20.86
µ
m;
P
< .001).
CONCLUSIONS:
The pulsed corneal cross-linking protocol induced a significantly deeper stromal demarcation line when compared to the 4 minutes of highly accelerated continuous CXL protocol. Neither CXL protocol induced a shallower demarcation line comparable to less accelerated CXL protocols previously reported.
[
J Refract Surg.
2016;32(3):206–208.]
Title: Stromal Demarcation Line in Pulsed Versus Continuous Light Accelerated Corneal Cross-linking for Keratoconus
Description:
PURPOSE:
To compare the stromal demarcation line depth in pulsed versus continuous corneal cross-linking (CXL) for keratoconus.
METHODS:
Seventy eyes underwent epithelium-off cross-linking, with 0.
1% riboflavin applied during 10 minutes prior to ultraviolet irradiation at 30 mW/cm
2
.
Thirty-six eyes received pulsed irradiation (1 second on, 1 second off) for 8 minutes and 34 eyes underwent continuous irradiation for 4 minutes.
Total fluence was 7.
2 J/cm
2
for both groups.
Patients were evaluated at 3 months after the procedure.
RESULTS:
A significantly deeper stromal demarcation line was observed in the pulsed group compared to the continuous group (201.
11 ± 27.
76 vs 159.
88 ± 20.
86
µ
m;
P
< .
001).
CONCLUSIONS:
The pulsed corneal cross-linking protocol induced a significantly deeper stromal demarcation line when compared to the 4 minutes of highly accelerated continuous CXL protocol.
Neither CXL protocol induced a shallower demarcation line comparable to less accelerated CXL protocols previously reported.
[
J Refract Surg.
2016;32(3):206–208.
].
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