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REM Sleep Behavior Disorder
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Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia featuring often violent dream enactment behavior, which may lead to injury. Its polysomnographic hallmark is loss of physiological REM muscle atonia. Prevalence is unknown but estimated to be less than 1% of the general adult population, and as high as 6% in the elderly. It is an important risk factor for development of alpha-synucleinopathy, with a conversion rate of approximately 80% after 15 years. Treatments include safeguarding the sleep environment, and clonazepam and/or melatonin to reduce injury. In the future, RBD diagnosis may provide an opportunity for new neuroprotective therapies.
Title: REM Sleep Behavior Disorder
Description:
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia featuring often violent dream enactment behavior, which may lead to injury.
Its polysomnographic hallmark is loss of physiological REM muscle atonia.
Prevalence is unknown but estimated to be less than 1% of the general adult population, and as high as 6% in the elderly.
It is an important risk factor for development of alpha-synucleinopathy, with a conversion rate of approximately 80% after 15 years.
Treatments include safeguarding the sleep environment, and clonazepam and/or melatonin to reduce injury.
In the future, RBD diagnosis may provide an opportunity for new neuroprotective therapies.
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