BPH Patofizyolojisi

Benign prostatic hyperplasia (BPH) is histological changes in the prostate that result in increased prostate volume and lower urinary tract symptoms. Although there are several reasons for the development of LUTS in BPH, the most important reason is the enlargement of the prostate gland. In addition, it has not been clarified why prostate size differs between individuals and why similar sizes cause different severity of LUTS. The aging of the world population has made BPH one of the most common diseases in men. The increase in the incidence of BPH has increased its socioeconomic cost. However, since its pathophysiology has not been fully elucidated, a new medical treatment alternative has not been established for years. In this review, possible different mechanisms that cause BPH to occur were examined and the literature on these mechanisms was reviewed. Keywords: prostate, hyperplasia, pathophysiology, androgens, inflamation