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COMPARISON OF PREEMPTIVE GABAPENTIN VERSUS PREGABALIN FOR RELIEF OF POSTOPERATIVE PAIN IN PATIENTS UNDERGOING OPEN CHOLECYSTECTOMY
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Background: Postoperative pain after open cholecystectomy is a serious clinical issue, which in many cases can be prevented by effective preemptive analgesia to improve patient outcomes and reduce opioid-related complications.
Purpose: To compare the efficacy of preemptive use of gabapentin and pregabalin in the management of postoperative pain in patients undergoing open cholecystectomy.
Methods: A randomized controlled trial was carried out on 60 patients who were divided into two groups. Group A was treated with 600 mg of gabapentin preoperative, and Group B was treated with 150 mg of pregabalin preoperative. The visual analogue scale was used to assess pain and time to first analgesic requirement was noted.
Findings: Pregabalin had a greater effect than gabapentin by significantly increasing the time to first analgesic requirement (108.2 ± 20.6 minutes). The pregabalin group also showed lower scores on postoperative pain.
Conclusion: Pregabalin is superior to gabapentin as a proactive analgesic, which has a better analgesic effect and requires less analgesic.
Insightful Education Research Institute
Title: COMPARISON OF PREEMPTIVE GABAPENTIN VERSUS PREGABALIN FOR RELIEF OF POSTOPERATIVE PAIN IN PATIENTS UNDERGOING OPEN CHOLECYSTECTOMY
Description:
Background: Postoperative pain after open cholecystectomy is a serious clinical issue, which in many cases can be prevented by effective preemptive analgesia to improve patient outcomes and reduce opioid-related complications.
Purpose: To compare the efficacy of preemptive use of gabapentin and pregabalin in the management of postoperative pain in patients undergoing open cholecystectomy.
Methods: A randomized controlled trial was carried out on 60 patients who were divided into two groups.
Group A was treated with 600 mg of gabapentin preoperative, and Group B was treated with 150 mg of pregabalin preoperative.
The visual analogue scale was used to assess pain and time to first analgesic requirement was noted.
Findings: Pregabalin had a greater effect than gabapentin by significantly increasing the time to first analgesic requirement (108.
2 ± 20.
6 minutes).
The pregabalin group also showed lower scores on postoperative pain.
Conclusion: Pregabalin is superior to gabapentin as a proactive analgesic, which has a better analgesic effect and requires less analgesic.
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