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Inhibition of glutamate dehydrogenase activity in rabbit renal mitochondria by phosphoenolpyruvate
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The effect of phosphoenolpyruvate on glutamate dehydrogenase activity was studied in both intact and Triton X‐100‐treated rabbit renal mitochondria. The intramitochondrial phosphoenolpyruvate content was modulated by application of both 3‐MPA, an inhibitor of phosphoenolpyruvate carboxykinase, and BTCA, which inhibits the tricarboxylate‐transporting system. The data indicate that: (i) phosphoenolpyruvate is a potent inhibitor of glutamate dehydrogenase activity; and (ii) its inhibitory effect on the enzyme may be abolished by leucine and ADP, activators of glutamate dehydrogenase.
Title: Inhibition of glutamate dehydrogenase activity in rabbit renal mitochondria by phosphoenolpyruvate
Description:
The effect of phosphoenolpyruvate on glutamate dehydrogenase activity was studied in both intact and Triton X‐100‐treated rabbit renal mitochondria.
The intramitochondrial phosphoenolpyruvate content was modulated by application of both 3‐MPA, an inhibitor of phosphoenolpyruvate carboxykinase, and BTCA, which inhibits the tricarboxylate‐transporting system.
The data indicate that: (i) phosphoenolpyruvate is a potent inhibitor of glutamate dehydrogenase activity; and (ii) its inhibitory effect on the enzyme may be abolished by leucine and ADP, activators of glutamate dehydrogenase.
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