Mac-2 Binding Protein Glycosylation Isomer as a Hepatocellular Carcinoma Marker in Patients with Chronic Hepatitis B or C Infection

Abstract Background Hpatocellular carcinoma HCC is now the sixth most common cause of cancer worldwide. The second leading cause of cancer death after lung cancer in men is HCC. The most frequently used screening tests for HCC patients are hepatic ultrasound (US) with or without assessment of alpha-fetoprotein, but the diagnostic value of AFP is recently challenged due to its low sensitivity and specificity. So the aim of this study was to evaluate the role of mac 2 as a diagnostic marker in HCC Egyptian patients. Objective This study will assess the role of Mac-2 Binding Protein Glycosylation Isomer as a Hepatocellular Carcinoma Marker in Patients With Chronic Hepatitis B or C Infection. Patients and Methods This study had been carried out on 70 subjects, age range more than 18 year selected from Internal medicine and Hepatology outpatient clinics and inpatient wards at Ain Shams university hospitals from august 2022 to june 2023, after informed consent were taken from the patients Results This study was carried out on 70 participants divided into 2 group: 35 patient post viral cirrhotic patients with Hepatocellular Carcinoma, 35 patient post viral cirrhotic patients without hepatocellar Carcinoma selected from Ain Shams university hospitals, after informed consent were taken from the patients. Subjects were divided as follow: Group A (Hcc): 35 patients with Hepatocellular carcinoma, More than 18 years. Group B (Cirrhotic): 35 patients with liver cirrhosis without Hepatocellular carcinoma, age more than 18 years Conclusion We concluded from this study that: Serum Mac2 level was significantly higher in patients with HCC regardless of other characteristics as presence of combined conditions as DM and HTN or Viral markers and mildly elevated in patients with liver cirrhosis compared to HCC group. MAC 2 is more sensitive than AFP in differentiation between HCC and cirrhoitic patients but AFP is more specific. Using of mac 2 will improve the diagnostic field and can help in early detection of HCC in surveillance programs Together with AFP.