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Data from Glycemic Index, Glycemic Load, and Lung Cancer Risk in Non-Hispanic Whites

<div>AbstractBackground: Postprandial glucose (PPG) and insulin responses play a role in carcinogenesis. We evaluated the association between dietary glycemic index (GI) and glycemic load (GL), markers of carbohydrate intake and PPG, and lung cancer risk in non-Hispanic whites.Methods: GL and GI were assessed among 1,905 newly diagnosed lung cancer cases recruited from the University of Texas MD Anderson Cancer Center (Houston, TX) and 2,413 healthy controls recruited at Kelsey-Seybold Clinics (Houston, TX). We assessed associations between quintiles of GI/GL and lung cancer risk and effect modification by various risk factors. ORs and 95% confidence intervals (CI) were estimated using multivariable logistic regression.Results: We observed a significant association between GI [5th vs. 1st quintile (Q) OR = 1.49; 95% CI, 1.21–1.83; Ptrend <0.001] and lung cancer risk and GIac (5th vs. 1st Q OR = 1.48; 95% CI, 1.20–1.81; Ptrend = 0.001) and lung cancer risk. We observed a more pronounced association between GI and lung cancer risk among never smokers (5th vs. 1st Q OR = 2.25; 95% CI, 1.42–3.57), squamous cell carcinomas (SCC; 5th vs. 1st Q OR = 1.92; 95% CI, 1.30–2.83), and those with less than 12 years of education (5th vs. 1st Q OR = 1.75; 95% CI, 1.19–2.58, Pinteraction = 0.02).Conclusion: This study suggests that dietary GI and other lung cancer risk factors may jointly and independently influence lung cancer etiology.Impact: Understanding the role of GI in lung cancer could inform prevention strategies and elucidate biologic pathways related to lung cancer risk. Cancer Epidemiol Biomarkers Prev; 25(3); 532–9. ©2016 AACR.</div>

American Association for Cancer Research (AACR)

Stephanie C. Melkonian Carrie R. Daniel Yuanqing Ye Jeanne A. Pierzynski Jack A. Roth Xifeng Wu

2023

Title: Data from Glycemic Index, Glycemic Load, and Lung Cancer Risk in Non-Hispanic Whites

Description:

<div>AbstractBackground: Postprandial glucose (PPG) and insulin responses play a role in carcinogenesis.

We evaluated the association between dietary glycemic index (GI) and glycemic load (GL), markers of carbohydrate intake and PPG, and lung cancer risk in non-Hispanic whites.

Methods: GL and GI were assessed among 1,905 newly diagnosed lung cancer cases recruited from the University of Texas MD Anderson Cancer Center (Houston, TX) and 2,413 healthy controls recruited at Kelsey-Seybold Clinics (Houston, TX).

We assessed associations between quintiles of GI/GL and lung cancer risk and effect modification by various risk factors.

ORs and 95% confidence intervals (CI) were estimated using multivariable logistic regression.

Results: We observed a significant association between GI [5th vs.

1st quintile (Q) OR = 1.

49; 95% CI, 1.

21–1.

83; Ptrend <0.

001] and lung cancer risk and GIac (5th vs.

1st Q OR = 1.

48; 95% CI, 1.

20–1.

81; Ptrend = 0.

001) and lung cancer risk.

We observed a more pronounced association between GI and lung cancer risk among never smokers (5th vs.

1st Q OR = 2.

25; 95% CI, 1.

42–3.

57), squamous cell carcinomas (SCC; 5th vs.

1st Q OR = 1.

92; 95% CI, 1.

30–2.

83), and those with less than 12 years of education (5th vs.

1st Q OR = 1.

75; 95% CI, 1.

19–2.

58, Pinteraction = 0.

02).

Conclusion: This study suggests that dietary GI and other lung cancer risk factors may jointly and independently influence lung cancer etiology.

Impact: Understanding the role of GI in lung cancer could inform prevention strategies and elucidate biologic pathways related to lung cancer risk.

Cancer Epidemiol Biomarkers Prev; 25(3); 532–9.

</div>.

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Glycemic Index, Glycemic Load, and Lung Cancer Risk in Non-Hispanic Whites

Abstract Background: Postprandial glucose (PPG) and insulin responses play a role in carcinogenesis. We evaluated the association between dietary glycemic index (...

Data from Glycemic Index, Glycemic Load, and Lung Cancer Risk in Non-Hispanic Whites

<div>AbstractBackground: Postprandial glucose (PPG) and insulin responses play a role in carcinogenesis. We evaluated the association between diet...

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Data from Glycemic Index, Glycemic Load, and Lung Cancer Risk in Non-Hispanic Whites

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