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Myocardial protection with Glucose-Insulin-Potassiuminfusion during adult cardiac surgery
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Background & Objective: Recent meta-analysis reports have called for more randomized trials to evaluate the effectiveness of GIK solution in patients of cardiac surgery. So this study was conducted to evaluate the effectiveness of Glucose-insulin-potassium (GIK) solutions in non-diabetic patients undergoing coronary artery bypass grafting.Methods: A total number of one hundred and sixty (160) patients were randomized into two equal groups; GIK Group and non-GIK group. In GIK group, 5% dextrose containing 70 IU/L regular insulin and 70 meq/L of potassium was administered. The infusion was started at a rate of 30 ml/hour after induction of anesthesia and before the start of cardiopulmonary bypass. The infusion was started again after removal of aortic cross clamp and was continued for six hours after the operation.Results: In early post-operative period, peak CKMB levels were high in non-GIK group 48.50
Pakistan Journal of Medical Sciences
Title: Myocardial protection with Glucose-Insulin-Potassiuminfusion during adult cardiac surgery
Description:
Background & Objective: Recent meta-analysis reports have called for more randomized trials to evaluate the effectiveness of GIK solution in patients of cardiac surgery.
So this study was conducted to evaluate the effectiveness of Glucose-insulin-potassium (GIK) solutions in non-diabetic patients undergoing coronary artery bypass grafting.
Methods: A total number of one hundred and sixty (160) patients were randomized into two equal groups; GIK Group and non-GIK group.
In GIK group, 5% dextrose containing 70 IU/L regular insulin and 70 meq/L of potassium was administered.
The infusion was started at a rate of 30 ml/hour after induction of anesthesia and before the start of cardiopulmonary bypass.
The infusion was started again after removal of aortic cross clamp and was continued for six hours after the operation.
Results: In early post-operative period, peak CKMB levels were high in non-GIK group 48.
50.
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