Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
MECHANISMS IN ENDOCRINOLOGY: Autoimmune hypopituitarism: novel mechanistic insights
View through CrossRef
Hypopituitarism is caused by various insults to the pituitary, such as hypothalamic and pituitary tumors, inflammation, autoimmunity, vascular injury, genetic abnormalities, irradiation, and trauma. Recently, it has been found that autoimmunity to the pituitary involves many pathological conditions associated with specific or non-specific hormone deficiencies in the gland. This review discusses the recent findings on the underlying mechanism of autoimmune hypopituitarism particularly of lymphocytic hypophysitis, IgG4-related hypophysitis, immune checkpoint inhibitor-induced hypophysitis, anti-PIT-1 hypophysitis, and isolated ACTH deficiency.
Title: MECHANISMS IN ENDOCRINOLOGY: Autoimmune hypopituitarism: novel mechanistic insights
Description:
Hypopituitarism is caused by various insults to the pituitary, such as hypothalamic and pituitary tumors, inflammation, autoimmunity, vascular injury, genetic abnormalities, irradiation, and trauma.
Recently, it has been found that autoimmunity to the pituitary involves many pathological conditions associated with specific or non-specific hormone deficiencies in the gland.
This review discusses the recent findings on the underlying mechanism of autoimmune hypopituitarism particularly of lymphocytic hypophysitis, IgG4-related hypophysitis, immune checkpoint inhibitor-induced hypophysitis, anti-PIT-1 hypophysitis, and isolated ACTH deficiency.
Related Results
Fertility and Pregnancy in Women With Hypopituitarism: A Systematic Literature Review
Fertility and Pregnancy in Women With Hypopituitarism: A Systematic Literature Review
AbstractContextHuman reproduction is mainly governed from the hypothalamic–adrenal–gonadal (HPG) axis, which controls both ovarian morphology and function. Disturbances in the secr...
Sex Steroid Levels in Women With Hypopituitarism: A Case-controlled Observational Study
Sex Steroid Levels in Women With Hypopituitarism: A Case-controlled Observational Study
Abstract
Context
Women with hypopituitarism remain at increased risk of morbidity and mortality. Insufficient replacement of sex...
Autoimmune Epilepsy - Novel Multidisciplinary Analysis, Discoveries and Insights
Autoimmune Epilepsy - Novel Multidisciplinary Analysis, Discoveries and Insights
Epilepsy affects ~50 million people. In ~30% of patients the etiology is unknown, and ~30% are unresponsive to anti-epileptic drugs. Intractable epilepsy often leads to multiple se...
Antipituitary antibodies after traumatic brain injury: is head trauma-induced pituitary dysfunction associated with autoimmunity?
Antipituitary antibodies after traumatic brain injury: is head trauma-induced pituitary dysfunction associated with autoimmunity?
ObjectiveTraumatic brain injury (TBI) is a devastating public health problem that may result in hypopituitarism. However, the mechanisms responsible for hypothalamic–pituitary dysf...
Two Rare Cases of Severe Autoimmune Dyserythropoiesis without Any Underlying Haematological Malignancy or Autoimmune Disease
Two Rare Cases of Severe Autoimmune Dyserythropoiesis without Any Underlying Haematological Malignancy or Autoimmune Disease
Background:
Autoimmune dyserythropoiesis is a rare disorder with only 4 adult cases and 3 paediatric cases reported in the literature. These suggest an underlying ca...
Analysis of the causes and clinical course of thyroid diseases in the presence of autoimmune overlap syndrome
Analysis of the causes and clinical course of thyroid diseases in the presence of autoimmune overlap syndrome
In recent years, the prevalence of autoimmune thyroid diseases, particularly autoimmune thyroiditis and Graves’ disease, has increased. These conditions sometimes co‑occur as part ...
Abstract 1784: IL-7R targeting therapy for immunoregulation and overcoming steroid resistance in cancer and autoimmune disease
Abstract 1784: IL-7R targeting therapy for immunoregulation and overcoming steroid resistance in cancer and autoimmune disease
Abstract
The occurrence of autoimmune reactions caused by immune checkpoint blockade in the treatment of cancer indicates the importance of the cross-disciplinary st...
THE POTENTIAL OF GLP-1 IN THE TREATMENT OF AUTOIMMUNE DISEASES: A REVIEW OF MECHANISMS AND CLINICAL DATA
THE POTENTIAL OF GLP-1 IN THE TREATMENT OF AUTOIMMUNE DISEASES: A REVIEW OF MECHANISMS AND CLINICAL DATA
Introduction: Autoimmune diseases are a heterogeneous group of disorders characterized by dysregulated immune responses against self-antigens, leading to chronic inflammation and p...