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NIR‐II Fluorescence Endoscopy for Targeted Imaging of Colorectal Cancer
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AbstractEndoscopy is a clinical gold standard to exam the interior of a hollow organ or body cavity. For the first of time, this study presents the design and construction of a fluorescent endoscopic system that harnesses the power of the second near‐infrared window II (NIR‐II) fluorescence imaging. An NIR‐II fluorescent molecular probe, indocyanine green (ICG) conjugated bevacizumab (Bev‐ICG) that targets vascular endothelial growth factor (VEGF), is successfully synthesized and evaluated along with the NIR‐II endoscopy imaging system. Simultaneous NIR‐II fluorescence and white‐light (WL) imaging of VEGF is validated in an orthotopic rat colorectal cancer model. This NIR‐II endoscopy system is a generalizable design, and it is compatible with the most of current clinic endoscopies. Similar hardware upgrades are expected to greatly promote the application of NIR‐II fluorescent imaging in the clinic.
Title: NIR‐II Fluorescence Endoscopy for Targeted Imaging of Colorectal Cancer
Description:
AbstractEndoscopy is a clinical gold standard to exam the interior of a hollow organ or body cavity.
For the first of time, this study presents the design and construction of a fluorescent endoscopic system that harnesses the power of the second near‐infrared window II (NIR‐II) fluorescence imaging.
An NIR‐II fluorescent molecular probe, indocyanine green (ICG) conjugated bevacizumab (Bev‐ICG) that targets vascular endothelial growth factor (VEGF), is successfully synthesized and evaluated along with the NIR‐II endoscopy imaging system.
Simultaneous NIR‐II fluorescence and white‐light (WL) imaging of VEGF is validated in an orthotopic rat colorectal cancer model.
This NIR‐II endoscopy system is a generalizable design, and it is compatible with the most of current clinic endoscopies.
Similar hardware upgrades are expected to greatly promote the application of NIR‐II fluorescent imaging in the clinic.
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