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Senile dementia of the neurofibrillary tangle type (tangle‐only dementia): Neuropathological criteria and clinical guidelines for diagnosis*
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Senile dementia of the NFT type (SD‐NFT) is a subset of dementia in the elderly, characterized by numerous NFT in the hippocampal region and absence or scarcity of senile plaques throughout the brain. Senile dementia‐NFT has also been referred to as tangle‐only dementia, NFT‐predominant form of SD, SD with tangles, or limbic NFT dementia. Herein are proposed the criteria for neuropathological diagnosis of SD‐NFT: (i) late‐onset dementia with abundant NFT in the hippocampal region and absence or scarcity of senile plaques (amyloid β protein deposits) throughout the brain; and (ii) exclusion of other dementias with NFT. Some elderly individuals suffering from memory disorder without obvious dementia have neuropathological findings similar to SD‐NFT, and they would represent a condition in the process of formation of the SD‐NFT pathology. Guidelines for the clinical diagnosis of SD‐NFT are also proposed; development of reliable diagnostic tests is necessary to differentiate AD and other neurodegenerative dementias from SD‐NFT.
Title: Senile dementia of the neurofibrillary tangle type (tangle‐only dementia): Neuropathological criteria and clinical guidelines for diagnosis*
Description:
Senile dementia of the NFT type (SD‐NFT) is a subset of dementia in the elderly, characterized by numerous NFT in the hippocampal region and absence or scarcity of senile plaques throughout the brain.
Senile dementia‐NFT has also been referred to as tangle‐only dementia, NFT‐predominant form of SD, SD with tangles, or limbic NFT dementia.
Herein are proposed the criteria for neuropathological diagnosis of SD‐NFT: (i) late‐onset dementia with abundant NFT in the hippocampal region and absence or scarcity of senile plaques (amyloid β protein deposits) throughout the brain; and (ii) exclusion of other dementias with NFT.
Some elderly individuals suffering from memory disorder without obvious dementia have neuropathological findings similar to SD‐NFT, and they would represent a condition in the process of formation of the SD‐NFT pathology.
Guidelines for the clinical diagnosis of SD‐NFT are also proposed; development of reliable diagnostic tests is necessary to differentiate AD and other neurodegenerative dementias from SD‐NFT.
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