Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Senile dementia of the neurofibrillary tangle type (tangle‐only dementia): Neuropathological criteria and clinical guidelines for diagnosis*
View through CrossRef
Senile dementia of the NFT type (SD‐NFT) is a subset of dementia in the elderly, characterized by numerous NFT in the hippocampal region and absence or scarcity of senile plaques throughout the brain. Senile dementia‐NFT has also been referred to as tangle‐only dementia, NFT‐predominant form of SD, SD with tangles, or limbic NFT dementia. Herein are proposed the criteria for neuropathological diagnosis of SD‐NFT: (i) late‐onset dementia with abundant NFT in the hippocampal region and absence or scarcity of senile plaques (amyloid β protein deposits) throughout the brain; and (ii) exclusion of other dementias with NFT. Some elderly individuals suffering from memory disorder without obvious dementia have neuropathological findings similar to SD‐NFT, and they would represent a condition in the process of formation of the SD‐NFT pathology. Guidelines for the clinical diagnosis of SD‐NFT are also proposed; development of reliable diagnostic tests is necessary to differentiate AD and other neurodegenerative dementias from SD‐NFT.
Title: Senile dementia of the neurofibrillary tangle type (tangle‐only dementia): Neuropathological criteria and clinical guidelines for diagnosis*
Description:
Senile dementia of the NFT type (SD‐NFT) is a subset of dementia in the elderly, characterized by numerous NFT in the hippocampal region and absence or scarcity of senile plaques throughout the brain.
Senile dementia‐NFT has also been referred to as tangle‐only dementia, NFT‐predominant form of SD, SD with tangles, or limbic NFT dementia.
Herein are proposed the criteria for neuropathological diagnosis of SD‐NFT: (i) late‐onset dementia with abundant NFT in the hippocampal region and absence or scarcity of senile plaques (amyloid β protein deposits) throughout the brain; and (ii) exclusion of other dementias with NFT.
Some elderly individuals suffering from memory disorder without obvious dementia have neuropathological findings similar to SD‐NFT, and they would represent a condition in the process of formation of the SD‐NFT pathology.
Guidelines for the clinical diagnosis of SD‐NFT are also proposed; development of reliable diagnostic tests is necessary to differentiate AD and other neurodegenerative dementias from SD‐NFT.
Related Results
Evaluating the Science to Inform the Physical Activity Guidelines for Americans Midcourse Report
Evaluating the Science to Inform the Physical Activity Guidelines for Americans Midcourse Report
Abstract
The Physical Activity Guidelines for Americans (Guidelines) advises older adults to be as active as possible. Yet, despite the well documented benefits of physical a...
Bacterial Amyloid and DNA are Important Constituents of Senile Plaques: Further Evidence of the Spirochetal and Biofilm Nature of Senile Plaques
Bacterial Amyloid and DNA are Important Constituents of Senile Plaques: Further Evidence of the Spirochetal and Biofilm Nature of Senile Plaques
It has long been known that spirochetes form clumps or micro colonies in vitro and in vivo. Cortical spirochetal colonies in syphilitic dementia were considered as reproductive cen...
Exploring Large Language Models Integration in the Histopathologic Diagnosis of Skin Diseases: A Comparative Study
Exploring Large Language Models Integration in the Histopathologic Diagnosis of Skin Diseases: A Comparative Study
Abstract
Introduction
The exact manner in which large language models (LLMs) will be integrated into pathology is not yet fully comprehended. This study examines the accuracy, bene...
Prescription Patterns of Anti-dementia and Psychotropic Drugs in People Living With Dementia in China
Prescription Patterns of Anti-dementia and Psychotropic Drugs in People Living With Dementia in China
Abstract
Pharmacotherapy of dementia is a critical intervention for managing symptoms of and slowing progression of dementia. However, evidence on prescribing patter...
Efficacy Of Kokila Varti Anjana In Comparison With Ilaneer Kuzhampu Anjana In Immature Senile Cataract- A Randomized Control Trial.
Efficacy Of Kokila Varti Anjana In Comparison With Ilaneer Kuzhampu Anjana In Immature Senile Cataract- A Randomized Control Trial.
ABSTRACT
According to WHO, globally cataract has remained the major cause of blindness over the years. In India prevalence of blindness was reported to be 8% in the age group of m...
Neuropathology of schizophrenia: A mini review
Neuropathology of schizophrenia: A mini review
The neuropathology of schizophrenia remains obscure despite the fact that many neuropathologists have investigated this area for over 100 years. While remarkable progress has been ...
Association of baseline dementia stage with cognitive markers during follow‐up in patients with dementia of Alzheimer type with and without post‐mortem Alzheimer pathology
Association of baseline dementia stage with cognitive markers during follow‐up in patients with dementia of Alzheimer type with and without post‐mortem Alzheimer pathology
AbstractBackgroundPrediction of the course of cognitive function is of central importance in the care of patients with dementia of Alzheimer type (DAT) for individual management, c...
MBI‐apathy, ApoEɛ2, and risk for Alzheimer disease dementia
MBI‐apathy, ApoEɛ2, and risk for Alzheimer disease dementia
AbstractBackgroundApathy, characterized by decreased interest, initiative, and emotional reactivity, is amongst the most common neuropsychiatric symptoms in dementia. However, apat...