Modern Pharmacotherapies Revivify Patulous Eustachian Tube as Di Bartolomeo's Syndrome of Misophonic Autophony

Objectives:1) Analyze the contemporary etiologic factors for the increasing incidence of rare patulous Eustachian Tube (PET) disorders within this century. 2) Enable physicians to recognize this elusive syndrome in the clinical otologic history and physical examination. 3) Identify the specific etiologies causing the PET in Di Bartolomeo's Syndrome of pathognomic autophony and the complex factors that enable the disturbing autogenic tubular sounds.Methods:Double blind, random clinical trial, employing the preferred topical nasal medication. A collateral PET study (2002‐2006) to formulate a drug‐free remedy which supports healing and tissue strength, within the generally regarded as safe (GRAS) Food and Drug Administration standards. The National Institutes of Health, and collateral PET support group social media forum, informed new PET inquirers of The Ear Foundation's former research website.160 subjects completed the study. In the online forum, 3,500 PET patients (4,000 ears) were treated. The results of the investigational new drug clinical trials and separate drug‐free study are presented.Results:Recent scientific and cultural advances in this century are identified which facilitate the evolution and increase in patients with disabling PET symptoms. Each has an individual multi‐factorial and enigmatic etiology and mechanism of action.Conclusions:None provided by author.