Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Genetic mapping of the gene for androgen-binding protein/sex hormone-binding globulin to mouse Chromosome 11
View through CrossRef
Southern blot analysis of DNAs from Chinese hamster × mouse and rat × mouse somatic cell hybrids showed that the mouse gene encoding androgen-binding protein/sex hormone-binding globulin (ABP-SHBG) is on Chromosome 11. Progeny from an intersubspecies backcross were analyzed to position this locus, termed <i>Shbg, </i>between <i>Il-3 </i>and <i>Int-4 </i>in the middle of this chromosome. <i>Shbg </i>is thus closely linked to several neurological mutations, one of which, <i>Tr, </i>is also associated with male sterility. The recent finding that ABP-SHBG is found throughout the rat brain raises the possibility that one of these mutations may be due to a defect in <i>Shbg.</i>
Title: Genetic mapping of the gene for androgen-binding protein/sex hormone-binding globulin to mouse Chromosome 11
Description:
Southern blot analysis of DNAs from Chinese hamster × mouse and rat × mouse somatic cell hybrids showed that the mouse gene encoding androgen-binding protein/sex hormone-binding globulin (ABP-SHBG) is on Chromosome 11.
Progeny from an intersubspecies backcross were analyzed to position this locus, termed <i>Shbg, </i>between <i>Il-3 </i>and <i>Int-4 </i>in the middle of this chromosome.
<i>Shbg </i>is thus closely linked to several neurological mutations, one of which, <i>Tr, </i>is also associated with male sterility.
The recent finding that ABP-SHBG is found throughout the rat brain raises the possibility that one of these mutations may be due to a defect in <i>Shbg.
</i>.
Related Results
Sex differences in disease genetics
Sex differences in disease genetics
AbstractThere is long-standing evidence for gene-by-sex interactions in disease risk, which can now be tested in genome-wide association studies with participant numbers in the hun...
RETRACTED: Isolation and Characterization of Antibacterial Conglutinins from Lupine Seeds
RETRACTED: Isolation and Characterization of Antibacterial Conglutinins from Lupine Seeds
The main target of this work is to discover new protein fractions from natural resources with high antibacterial action. The 7S and 11S globulin fractions, as well as the basic sub...
Construction of stable mouse artificial chromosome from native mouse chromosome 10 for generation of transchromosomic mice
Construction of stable mouse artificial chromosome from native mouse chromosome 10 for generation of transchromosomic mice
AbstractMammalian artificial chromosomes derived from native chromosomes have been applied to biomedical research and development by generating cell sources and transchromosomic (T...
Construction of Stable Mouse Artificial Chromosome from Native Mouse Chromosome 10 for Generation of Transchromosomic Mice
Construction of Stable Mouse Artificial Chromosome from Native Mouse Chromosome 10 for Generation of Transchromosomic Mice
Abstract
Mammalian artificial chromosomes derived from native chromosomes have been applied to biomedical research and development by generating cell sources and transchrom...
Endothelial Protein C Receptor
Endothelial Protein C Receptor
IntroductionThe protein C anticoagulant pathway plays a critical role in the negative regulation of the blood clotting response. The pathway is triggered by thrombin, which allows ...
Abstract B006: Development of a novel therapeutic splice-switching oligonucleotide targeting race-related androgen receptor signaling and aggressive prostate cancer
Abstract B006: Development of a novel therapeutic splice-switching oligonucleotide targeting race-related androgen receptor signaling and aggressive prostate cancer
Abstract
Background: Age-adjusted incidence and mortality rates for prostate cancer (PCa) among African American (AA) men are 1.6- and 2.4-fold greater, respectively...
Abstract PR04: Development of a novel therapeutic splice-switching oligonucleotide targeting race-related androgen receptor signaling and aggressive prostate cancer
Abstract PR04: Development of a novel therapeutic splice-switching oligonucleotide targeting race-related androgen receptor signaling and aggressive prostate cancer
Abstract
Background: Age-adjusted incidence and mortality rates for prostate cancer (PCa) among African American (AA) men are 1.6- and 2.4-fold greater, respectively...
Expression and polymorphism of genes in gallstones
Expression and polymorphism of genes in gallstones
ABSTRACT
Through the method of clinical case control study, to explore the expression and genetic polymorphism of KLF14 gene (rs4731702 and rs972283) and SR-B1 gene (rs...